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The use of population encoding models has come to dominate the study of human vision, serving as a primary tool for making inferences about neuroscience studies neural code changes based on indirect measurements. A popular approach in computational neuroimaging is to use such models to obtain estimates of neural population responses via IEM. Recent research suggests that this approach may be prone to identifiability problems, with multiple mechanisms of encoding change producing similar changes in the estimated population responses. Psychophysical data might be able to provide additional constraints to infer the encoding change mechanism underlying some behavior of interest. Here, we used simulation to explore exactly which of a number of changes in neural population codes could be differentiated from observed changes in psychophysical thresholds. Eight mechanisms of encoding change were under study: specific and nonspecific gain, specific and nonspecific tuning, specific suppression, specific suppression plus gain, and inward and outward tuning shifts. We simulated psychophysical thresholds as a function of both external noise (TvN curves) or stimulus value (TvS curves) for a number of variations of each one of the models. With the exception of specific gain and specific tuning, all mechanisms produced qualitatively different patterns of change in the TvN and TvS curves, suggesting that psychophysical studies can be used as a complement to IEM, and provide constraints on inferences based on the latter. We use our results to provide recommendations for researchers and to re-interpret previous psychophysical data in terms of mechanisms of encoding change.